Tottenham vs Newcastle United
Two of the Premier League's form sides in the autumn, with contrasting styles. Tottenham's high-energy attacking football against Newcastle's more direct, Isak-focused approach. The Geordie support will travel in numbers regardless of the mid-week date, and St James' Park would be a ferocious atmosphere if the tie is played at home. The edge may come from depth: Tottenham's squad, stretched by European commitments, has been tested lately.
Prediction: Newcastle United, on penalties
Chelsea vs Leicester City
Leicester, promoted back to the Premier League this season, have used the League Cup to field a youthful side — and have beaten two top-half opponents in earlier rounds through sheer organisation and set-piece efficiency. Chelsea, despite being favourites on paper, have dropped points in similar fixtures this season when underestimating promoted opposition. Maresca must guard against complacency.