Four Premier League clubs have already secured their places in the Champions League last 16 this season — Arsenal, Chelsea, Manchester City and Newcastle United — with two matchdays of the league phase still to play. The draw for the knockout round takes place in January, and while the exact seedings will depend on final league phase standings, we can already begin to map out the likely landscape of opponents and assess which of England's representatives has the clearest path to the quarter-finals.
Arsenal: The Likely Top Seed
Arsenal have been exceptional in Europe this season. Five wins and a draw from their first six league phase games — including a memorable 3-1 victory over Bayern Munich at the Emirates — has established them as genuine contenders and near-certain top seeds. As a seeded team in the last 16, Arsenal will play the first leg at home, which is a significant advantage.
Likely opponents for the Gunners include Benfica, PSV Eindhoven or Girona — teams who are likely to finish as runners-up in their section of the league phase table. While none of those matchups would be a walkover, Arsenal's current European form suggests they are capable of progressing against any of them. The main concern is their depth in key positions: a two-legged tie in February asks serious questions of squad thickness.